Triethylamine → HCID 86611739、化合物

HRID 2239860ノート

反応式

HRID 2239860 の反応式
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[CH:8][CH:9]=1.C(N(CC)CC)C.[Br:18][C:19]1[N:23]2[N:24]=[C:25]([Cl:29])[CH:26]=[C:27](Br)[C:22]2=[N:21][CH:20]=1>CCO>[Br:18][C:19]1[N:23]2[N:24]=[C:25]([Cl:29])[CH:26]=[C:27]([NH:10][C:7]3[CH:8]=[CH:9][C:4]([O:3][CH2:2][CH3:1])=[CH:5][CH:6]=3)[C:22]2=[N:21][CH:20]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 90764-EthoxyanilineHCID 446307233,8-Dibromo-6-chloroimidazo[1,2-b]pyridazine

生成物 1

HCID 86611739HCID 86611739、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

p-Phenetidine (0.38 ml, 2.9 mmol) and triethylamine (0.8 ml, 5.8 mmol) were added to a mixture of 3,8-dibromo-6-chloroimidazo[1,2-b]pyridazine (0.83 g, 2.67 mmol) from 1a in EtOH (10 mL). The mixture was heated to 80° C. and stirred for 16 hrs. The solution was then concentrated in vacuo to give crude 3-bromo-6-chloro-N-(4-ethoxyphenyl)imidazo[1,2-b]pyridazin-8-amine.

後処理

  1. concentrationThe solution was then concentrated in vacuo

出典と根拠

ORDレコード
ord-22aefa9687de43a08b620f0d46b1c95b
出典データセット
uspto-grants-2010_05
特許番号
US07723336B2

反応ノート

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