4-Fluorobenzaldehyde → 4-(4-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one

反応式

F[C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[C:11](=[O:20])[N:10]([CH3:21])[C:9]=2[CH3:22])[CH:5]=[CH:6][CH:7]=1.[F:23]C1C=CC(C=O)=CC=1>>[F:23][C:7]1[CH:6]=[CH:5][C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[C:11](=[O:20])[N:10]([CH3:21])[C:9]=2[CH3:22])=[CH:3][CH:2]=1

参加物

反応物 2

HCID 680234-Fluorobenzaldehyde

HCID 117380444-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one

生成物 1

HCID 112549694-(4-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one

実験手順

Following the procedure for 4-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one, using (in Step A) 4-fluorobenzaldehyde in place of 3-fluorobenzaldehyde, the title compound was synthesized.

出典と根拠

ORDレコード: ord-5e490df5bf5246319897e3ac2e58d59a
出典データセット: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07723352B2

反応ノート

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