2,3-Dichlorophenyl Isothiocyanate → 1-(2,3-Dichloro-phenyl)-3-(2-fluoro-pyridin-4-ylmethyl)-thiourea

反応式

Cl.[F:2][C:3]1[CH:8]=[C:7]([CH2:9][NH2:10])[CH:6]=[CH:5][N:4]=1.[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[N:19]=[C:20]=[S:21]>>[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[NH:19][C:20]([NH:10][CH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([F:2])[CH:8]=1)=[S:21]

参加物

反応物 2

HCID 27962812,3-Dichlorophenyl Isothiocyanate

HCID 66524242(2-Fluoropyridin-4-yl)methanamine hydrochloride

生成物 1

HCID 860822871-(2,3-Dichloro-phenyl)-3-(2-fluoro-pyridin-4-ylmethyl)-thiourea収率 53%

実験手順

Prepared in 53% yield from the product of Example 143A and 2,3-dichlorophenylisothiocyanate according to the procedure described for Example 141B. MS (ESI+) m/z 329.9 (M+H)+; 1H NMR (DMSO-d6) δ 4.79 (d, J=5.8 Hz, 2H), 7.02 (br s, 1H), 7.26 (d, J=5.1 Hz, 1H), 7.39 (d, J=8.1 Hz, 1H), 7.48-7.61 (m, 2H), 8.18 (d, J=5.1 Hz, 1H), 8.43 (br s, 1H), 9.69 (br s, 1H).

出典と根拠

ORDレコード: ord-bb7c9a074fa840a0b9be235f52719e25
出典データセット: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07723367B2

反応ノート

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