tert-Butyl 2-bromopropanoate → 1,1-Dimethylethyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(3,3,3-trifluoropropyl)alaninate

HRID 2240893ノート

反応式

HRID 2240893 の反応式
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:10]=[C:9]([NH:11][CH2:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH:8]=[CH:7][C:4]=1[C:5]#[N:6].Br[CH:21]([CH3:29])[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>>[C:5]([C:4]1[CH:7]=[CH:8][C:9]([N:11]([CH2:12][CH2:13][C:14]([F:17])([F:16])[F:15])[C@H:21]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH3:29])=[CH:10][C:3]=1[C:2]([F:18])([F:19])[F:1])#[N:6]

参加物

3

反応物 2

HCID 545327tert-Butyl 2-bromopropanoateHCID 576337572-(Trifluoromethyl)-4-[(3,3,3-trifluoropropyl)amino]benzonitrile

生成物 1

HCID 866319971,1-Dimethylethyl N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(3,3,3-trifluoropropyl)alaninate

実験手順

Synthesized as described in example 1B using 2-(trifluoromethyl)-4-[(3,3,3-trifluoropropyl)amino]benzonitrile and 1,1-dimethylethyl 2-bromopropanoate. 1H NMR (400 MHz, CDCl3) δ 7.67 (d, J=8.8 Hz, 1H), 7.0 (d, J=2.6 Hz, 1H), 6.85 (dd, J=8.8, 2.6 Hz, 1H), 4.37 (q, J=7.3 Hz, 1H), 3.74 (t, J=8.1 Hz, 2H), 2.62-2.38 (m, 2H), 1.61 (d, J=7.3 Hz, 3H), 1.45 (s, 9H).

後処理

  1. customSynthesized

出典と根拠

ORDレコード
ord-f3976a1a47b64a2b8f5d0d82db8a1159
出典データセット
uspto-grants-2010_05
特許番号
US07723385B2

反応ノート

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