1-(Difluoromethoxy)-4-iodobenzene → 5-(4-Difluoromethoxy-phenylethynyl)-2-methoxy-benzonitrile

HRID 2240942ノート

反応式

HRID 2240942 の反応式
[F:1][CH:2]([F:11])[O:3][C:4]1[CH:9]=[CH:8][C:7](I)=[CH:6][CH:5]=1.[C:12]([C:14]1[CH:15]=[CH:16][C:17]([O:22][CH3:23])=[C:18]([CH:21]=1)[C:19]#[N:20])#[CH:13]>>[F:1][CH:2]([F:11])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:13]#[C:12][C:14]2[CH:15]=[CH:16][C:17]([O:22][CH3:23])=[C:18]([CH:21]=2)[C:19]#[N:20])=[CH:6][CH:5]=1

参加物

3

反応物 2

HCID 27370081-(Difluoromethoxy)-4-iodobenzeneHCID 534292965-Ethynyl-2-methoxybenzonitrile

生成物 1

HCID 575824365-(4-Difluoromethoxy-phenylethynyl)-2-methoxy-benzonitrile

実験手順

The title compound was prepared in substantially the same manner as described in Example 12, step 3 starting from 1-Difluoromethoxy-4-iodo-benzene (0.17 g, 0.64 mmol), and 5-Ethynyl-2-methoxy-benzonitrile (0.10 g, 0.64 mmol), and was obtained as a light brown solid, (0.170 g, 89%), identified by NMR and mass spectral analyses. MS (APPI+): 299 (M+)

後処理

  1. customwas obtained as a light brown solid, (0.170 g, 89%),

出典と根拠

ORDレコード
ord-f71e8f4c937b4197a215fe3d80b3d720
出典データセット
uspto-grants-2010_05
特許番号
US07723368B2

反応ノート

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