HCID 59306518、化合物 → Ethyl 3-cyano-2,4,5-trifluorobenzoate
反応式
O[N:2]=[CH:3][C:4]1[C:5]([F:17])=[C:6]([CH:12]=[C:13]([F:16])[C:14]=1[F:15])[C:7]([O:9][CH2:10][CH3:11])=[O:8]>ClC(Cl)(Cl)C#N>[C:3]([C:4]1[C:5]([F:17])=[C:6]([CH:12]=[C:13]([F:16])[C:14]=1[F:15])[C:7]([O:9][CH2:10][CH3:11])=[O:8])#[N:2]参加物
3
反応条件
- 温度
- 90 °C
実験手順
Ethyl 3-hydroxyiminomethyl-2,4,5-trifluorobenzoate (5.5 g, 24.0 mmol) was dissolved in trichloroacetonitrile (25 g), and the solution was stirred at 90° C. for 16 hours. The reaction mixture was left to cool, and the solid matter that precipitated was separated through filtration. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel chromatography (eluent; n-hexane ethyl acetate=10:1), to thereby yield the title compound as a colorless oily substance (3.35 g, 61%).