Ethyl 3-aminobenzoate → HCID 8823771、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH2:12]([O:14][C:15](=[O:23])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=1)[CH3:13]>C1(C)C=CC=CC=1>[CH2:12]([O:14][C:15](=[O:23])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][S:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)(=[O:10])=[O:9])[CH:17]=1)[CH3:13]参加物
4
反応条件
- 温度
- 100 °C
実験手順
A solution of 3-chloro-benzenesulfonyl chloride (2.68 g, 13.0 mmol) in toluene (10.0 ml) was warmed to 100° C. and treated with a solution of 3-amino-benzoic acid ethyl ester (2.00 g, 12.0 mmol) in toluene (10.0 ml). The mixture was stirred at 100° C. for 1 h, then cooled to 0° C. for 1 h. The precipitated solid was filtered, washing with toluene. Drying of the solid under high vacuum yielded 3-(3-chloro-benzenesulfonylamino)-benzoic acid ethyl ester (4.03 g, 98%) as an off-white solid, which was used crude in the following reaction.