Bromobenzene → 2-(4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

反応式

[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:12]3=[N:13][CH:14]=[CH:15][C:16](Cl)=[C:11]3[C:10]([I:18])=[N:9]2)=[CH:5][CH:4]=1.[F:21][C:22]1[CH:23]=[C:24]([NH:29][C:30]2[N:45]=[CH:44][CH:43]=[CH:42][C:31]=2[C:32]([NH:34][C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)=[O:33])[CH:25]=[CH:26][C:27]=1[OH:28].C(=O)([O-])[O-].[Cs+].[Cs+].BrC1C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:12]3=[N:13][CH:14]=[CH:15][C:16]([O:28][C:27]4[CH:26]=[CH:25][C:24]([NH:29][C:30]5[N:45]=[CH:44][CH:43]=[CH:42][C:31]=5[C:32]([NH:34][C:35]5[CH:36]=[CH:37][C:38]([F:41])=[CH:39][CH:40]=5)=[O:33])=[CH:23][C:22]=4[F:21])=[C:11]3[C:10]([I:18])=[N:9]2)=[CH:5][CH:4]=1