Hydrochloric Acid → HCID 59205166、化合物

反応式

Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)[N:3]=1.[NH2:21][C:22]1[CH:30]=[CH:29][C:28]2[CH2:27][CH2:26][CH2:25][C:24]=2[C:23]=1[S:31]([NH2:34])(=[O:33])=[O:32].Cl>C(O)(C)C>[CH3:20][O:19][C:11]1[CH:10]=[C:9]([NH:8][C:4]2[N:3]=[C:2]([NH:21][C:22]3[CH:30]=[CH:29][C:28]4[CH2:27][CH2:26][CH2:25][C:24]=4[C:23]=3[S:31]([NH2:34])(=[O:32])=[O:33])[CH:7]=[CH:6][N:5]=2)[CH:14]=[C:13]([O:15][CH3:16])[C:12]=1[O:17][CH3:18]

参加物

実験手順

(4-Chloro-pyrimidin-2-yl)-(3,4,5-trimethoxy-phenyl)-amine (240 mg, 0.81 mmol) and 5-amino-indan-4-sulfonic acid amide (190 mg, 0.89 mmol) are suspended in isopropanol (15 ml). Conc. HCl (1.5 ml) is added. The mixture is heated to reflux for 1 h. The reaction mixture is separated between ethyl acetate (300 ml) and water (100 ml). NaHCO3 is added to achieve basic pH. The layers are separated. The organic layer is dried with Na2SO4 and evaporated. The residue is crystallized from ethyl acetate to give 5-[2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-indan-4-sulfonic acid amide.