HCID 55091508、化合物 → HCID 178426363、化合物

HRID 2242046ノート

反応式

HRID 2242046 の反応式
[CH2:1]([N:8]([CH3:17])[C:9]1[CH:10]=[C:11]([NH2:16])[CH:12]=[CH:13][C:14]=1[CH3:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:18][C:19]1[CH:24]=[CH:23][N:22]=[C:21](SC)[N:20]=1>CO>[CH2:1]([N:8]([CH3:17])[C:9]1[CH:10]=[C:11]([NH:16][C:21]2[N:20]=[C:19]([OH:18])[CH:24]=[CH:23][N:22]=2)[CH:12]=[CH:13][C:14]=1[CH3:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 55091508HCID 55091508、化合物HCID 178503462HCID 178503462、化合物

生成物 1

HCID 178426363HCID 178426363、化合物収率 29.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
160 °C

実験手順

An intimate mixture of N3-benzyl-N3,4-dimethyl-benzene-1,3-diamine (158 mg, 0.7 mmol) and 4-hydroxy-2-methylthio-pyrimidine (109 mg, 0.77 mmol) is heated in an oil bath of 160° C. After 3 h the melt is cooled to room temperature and treated with MeOH. The remaining solid is collected by filtration, washed with MeOH, and dried, giving 65.5 mg (29%) of N3-benzyl-N1-(4-hydroxy-pyrimidin-2-yl)-N3,4-dimethyl-benzene-1,3-diamine.

後処理

  1. temperatureAfter 3 h the melt is cooled to room temperature
  2. filtrationThe remaining solid is collected by filtration
  3. washwashed with MeOH
  4. customdried

出典と根拠

ORDレコード
ord-3546a7cf43614cce88262d6920c38e13
出典データセット
uspto-grants-2010_03
特許番号
US07671063B2

反応ノート

読み込み中…