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Phenylsulphonyl isocyanate → N-[(4-Dimethylamino-6-methylpyrimidin-2-yl)aminocarbonyl]benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylsulphonyl isocyanate | HCID 76096 | — |
| 反応物 | N4,N4,6-trimethylpyrimidine-2,4-diamine | HCID 13729300 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-[(4-Dimethylamino-6-methylpyrimidin-2-yl)aminocarbonyl]benzenesulfonamide | HCID 23332186 | — |
反応手順
To a suspension of 15.2 g of 2-amino-4-dimethylamino-6-methylpyrimidine in 400 ml of methylene chloride at ambient temperature was added slowly 18.3 g of benzenesulfonylisocyanate. After stirring for four hours the mixture was stripped in-vacuo and the white semisolid residue triturated with ethyl ether and isolated by filtration. The solid was then slurried in hot acetone, cooled and refiltered to yield the solid named above which decomposed at 180°-182°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04231784 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-b4614a42cfa24a8fbd0ddc680ef7c32b |
| 出典メモ | uspto-grants-1980_11 |