HCID 69242804、化合物 → HCID 11675251、化合物
反応式
C(OC([N:8]1[CH2:12][C@@H:11]([CH2:13][NH:14][C:15](=[O:26])[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([O:24][CH3:25])=[O:23])[CH:17]=2)[CH2:10][C@H:9]1[C:27]([N:29]1[CH2:33][CH2:32][S:31][CH2:30]1)=[O:28])=O)(C)(C)C>Cl.O1CCOCC1>[CH3:25][O:24][C:22](=[O:23])[C:18]1[CH:19]=[CH:20][CH:21]=[C:16]([C:15]([NH:14][CH2:13][C@H:11]2[CH2:10][C@@H:9]([C:27]([N:29]3[CH2:33][CH2:32][S:31][CH2:30]3)=[O:28])[NH:8][CH2:12]2)=[O:26])[CH:17]=1参加物
4
実験手順
A solution of Example 18A (100 mg) in 4 M HCl in dioxane (2 mL) was stirred at room temperature for 16 hours, and concentrated under reduced pressure. The residue was taken up and concentrated under reduced pressure under the following solvents, methanol (10 mL), ether (10 mL) and dichloromethane (10 mL) to provide the titled compound as a pale yellow solid. MS (ESI) m/e 378 (M+H)+; 1H NMR (500 MHz, CD3OD): δ ppm 1.80 (m, 1 H), 2.74 (m, 1 H), 2.82 (m, 1 H), 3.09 (m, 1 H), 3.16 (q, 1 H), 3.23 (dd, 1 H), 3.33 (m, 1 H), 3.56 (m, 3 H), 3.74 (m, 1 H), 3.88 (m, 1 H), 3.93 (d, 3 H), 4.52 (m, 1 H), 4.67 (m, 2 H), 7.61 (m, 1 H), 8.07 (m, 1 H), 8.19 (d, 1 H), 8.49 (m, 1 H).