Carbon Dioxide → 5-Chloro-2-methanesulfonylpyrimidine
反応式
[Cl:1][C:2]1[C:3](C(O)=O)=[N:4][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[N:6][CH:7]=1.C(=O)=O>C1(OC)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([S:8]([CH3:11])(=[O:9])=[O:10])=[N:6][CH:7]=1参加物
4
実験手順
5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid (5.7 g, 24 mmol) was refluxed in anisole (8 mL) until the evolution of carbon dioxide ceased. The reaction mixture was cooled to room temperature and filtered. The solid was washed with light petroleum ether (1×50 mL) and dried to obtain the title compound (4.10 g, 88% yield) as a light orange solid.
後処理
- filtrationfiltered
- washThe solid was washed with light petroleum ether (1×50 mL)
- customdried
出典と根拠
- ORDレコード
- ord-3fb86334fa384e0dab4ce14d98102812
- 出典データセット
- uspto-grants-2010_03
- 特許番号
- US07671043B2
反応ノート
読み込み中…