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2-Amino-5-methylbenzoic acid → 2-Carboxy-4-methylcyclohexan-1-yl-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-5-methylbenzoic acid | HCID 76255 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Ruthenium carbon | HCID 16218582 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Carboxy-4-methylcyclohexan-1-yl-amine | HCID 14993976 | — |
反応手順
50 g (0.33 mol) of 2-amino-5-methyl-benzoic acid, dissolved in 100 ml of tetrahydrofuran, are hydrogenated for 14 hours at 200° C. and 200 bar hydrogen in the presence of 5 g of ruthenium/charcoal. After cooling and evaporation, 30 g o f 2-carboxy-4-methyl-cyclohexan-1-yl -amine are obtained as a pale oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05428073 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-7803faf4114942328d46e35a1e9d6188 |
| 出典メモ | uspto-grants-1995_06 |