Hydrochloric Acid → Methyl 5-(tert-butyl)-2-methoxybenzoate

HRID 2242349ノート

反応式

HRID 2242349 の反応式
Cl.[C:2]([C:6]1[CH:7]=[CH:8][C:9]([O:15][CH3:16])=[C:10]([CH:14]=1)[C:11]([OH:13])=[O:12])([CH3:5])([CH3:4])[CH3:3].[CH3:17]O>>[CH3:17][O:12][C:11](=[O:13])[C:10]1[CH:14]=[C:6]([C:2]([CH3:5])([CH3:3])[CH3:4])[CH:7]=[CH:8][C:9]=1[O:15][CH3:16]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 70103155-Tert-Butyl-2-Methoxybenzoic Acid

生成物 1

HCID 15724682Methyl 5-(tert-butyl)-2-methoxybenzoate収率 95%

実験手順

Hydrogen chloride gas was bubbled for 5 min into a stirred solution of 5-tert-butyl-2-methoxybenzoic acid (5.00 g, 24.0 mmol) in methanol (100 ml) at 0° C., after which time the solution was heated under reflux for 17.5 h. The reaction was cooled, evaporated to dryness under reduced pressure and purified by chromatography on silica using diethyl ether as eluent to afford 5-tert-butyl-2-methoxybenzoic acid methyl ester as a pale cream solid (5.06 g, 95%).

後処理

  1. temperatureafter which time the solution was heated
  2. temperatureunder reflux for 17.5 h
  3. temperatureThe reaction was cooled
  4. customevaporated to dryness under reduced pressure
  5. custompurified by chromatography on silica

出典と根拠

ORDレコード
ord-71d8ceecbad14df5be86f1c5ba47b85f
出典データセット
uspto-grants-2010_03
特許番号
US07671080B2

反応ノート

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