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1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1) → 5-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (1-hydroxy-cyclopentylmethyl)amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1) | HCID 21109693 | — |
| 反応物 | 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid | HCID 68543106 | — |
| 生成物 | 5-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (1-hydroxy-cyclopentylmethyl)amide | HCID 59205404 | — |
反応手順
The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and 1-aminomethyl-cyclopentanol hydrochloride in a manner similar to that described in Example 11.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07671080B2 |
| 出典データセット | uspto-grants-2010_03 |
| ORD ID | ord-8ebd830b48ed48a18716863ea10f4097 |
| 出典メモ | uspto-grants-2010_03 |