Ethyl 1-cyanocyclobutane-1-carboxylate → Ethyl 1-(aminomethyl)cyclobutanecarboxylate

HRID 2242384ノート

反応式

HRID 2242384 の反応式
[CH2:1]([O:3][C:4]([C:6]1([C:10]#[N:11])[CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].[H][H]>C(O)C.[Ni].O>[CH2:1]([O:3][C:4]([C:6]1([CH2:10][NH2:11])[CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2]

参加物

6

反応物 2

HCID 275343Ethyl 1-cyanocyclobutane-1-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 45122079Ethyl 1-(aminomethyl)cyclobutanecarboxylate収率 72%

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
40 °C

実験手順

1-Cyano-cyclobutanecarboxylic acid ethyl ester (2.00 g, 13.0 mmol) was dissolved in ethanol (30 ml) and treated with Raney Nickel (1 ml as a slurry in water) and hydrogen gas at 4 bar and heating at 40° C. for 18 h. The reaction mixture was filtered through Dicalite and washed through with ethanol (50 ml). The solvent was removed under reduced pressure to give 1-aminomethyl-cyclobutanecarboxylic acid ethyl ester as a yellow oil (1.47 g, 72%).

後処理

  1. filtrationThe reaction mixture was filtered through Dicalite
  2. washwashed through with ethanol (50 ml)
  3. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-a44dee56808f4538984451ebc3637586
出典データセット
uspto-grants-2010_03
特許番号
US07671080B2

反応ノート

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