HCID 59204172、化合物 → 5-((S)-1-tert-Butoxycarbonyl-propylcarbamoyl)-3-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopent-1-enecarboxylic acid

反応式

C[O:2][C:3]([C:5]1[CH:9]([C:10](=[O:22])[NH:11][C@H:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:13][CH3:14])[CH2:8][CH:7]([O:23][C:24]2[C:33]3[C:28](=[CH:29][C:30]([O:34][CH3:35])=[CH:31][CH:32]=3)[N:27]=[C:26]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH:25]=2)[CH:6]=1)=[O:4].C(OC([C@@H](NC(C1C(C(O)=O)=CC(OC2C3C(=CC(OC)=CC=3)N=C(C3C=CC=CC=3)C=2)C1)=O)CCC)=O)(C)(C)C>>[C:18]([O:17][C:15]([C@@H:12]([NH:11][C:10]([CH:9]1[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]([O:23][C:24]2[C:33]3[C:28](=[CH:29][C:30]([O:34][CH3:35])=[CH:31][CH:32]=3)[N:27]=[C:26]([C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH:25]=2)[CH2:8]1)=[O:22])[CH2:13][CH3:14])=[O:16])([CH3:19])([CH3:20])[CH3:21]

参加物

反応物 2

HCID 59204172HCID 59204172、化合物

HCID 592042075-((S)-1-tert-Butoxycarbonyl-propylcarbamoyl)-3-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopent-1-enecarboxylic acid methyl ester

生成物 1

HCID 592042055-((S)-1-tert-Butoxycarbonyl-propylcarbamoyl)-3-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopent-1-enecarboxylic acid

実験手順

Reaction of 9 (225 mg, 40 mmol) according to the method described for the preparation of 11 provided the title compound as a yellow salt (157 mg, 72%).

出典と根拠

ORDレコード: ord-5a87f5ef326c453aaa8deae5ab40741b
出典データセット: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07671032B2

反応ノート

読み込み中…