Hydrochloric Acid → Ethyl 3,4-dichlorophenylacetate

HRID 224288

反応式

HRID 224288 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH2:14](O)[CH3:15]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:14][CH3:15])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 798743,4-Dichlorophenylacetic acid

生成物 1

HCID 2737422Ethyl 3,4-dichlorophenylacetate

実験手順

A solution of 59.5 g of 3,4-dichlorophenylacetic acid in 500 ml of absolute ethanol is saturated with anhydrous hydrogen chloride and then heated at reflux for 2 hours. The mixture is concentrated under reduced pressure to 200 ml, diluted with 200 ml of water and neutralized with concentrated ammonium hydroxide. This aqueous mixture is extracted 3 times with chloroform. Concentration and decolorization of the chloroform extracts gives ethyl 3,4-dichlorophenylacetate as a yellow oil.

後処理

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. concentrationThe mixture is concentrated under reduced pressure to 200 ml
  4. additiondiluted with 200 ml of water and neutralized with concentrated ammonium hydroxide
  5. extractionThis aqueous mixture is extracted 3 times with chloroform
  6. concentrationConcentration and decolorization of the chloroform

出典と根拠

ORDレコード
ord-291ab04acfd64a1e845e3da713d14741
出典データセット
uspto-grants-1980_11
特許番号
US04231935

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