化工社化工社 化学情報印刷レポート · 研究参考用
Water → HCID 178512066、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Furonitrile | HCID 69245 | — |
| 反応物 | 2-Amino-3,5-dibromopyrazine | HCID 620004 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 生成物 | HCID 178512066 | HCID 178512066 | 72% |
反応手順
A solution of 3,5-dibromo-pyrazin-2-ylamine (608 mg, 2.4 mmol), furan-2-carbonitrile (297 uL, 3.39 mmol) and AlCl3 (320 mg, 2.4 mmol) in dichloroethane (6 ml) was heated at 115° C. overnight. The reaction was cooled to room temperature and water (5 ml) was added. After 30 minutes, the resulting precipitate was collected and purified by column chromatography (SiO2, THF) to afford 595 mg (72%) of N-(3,5-dibromo-pyrazin-2-yl)-furan-2-carboxamidine as a yellow solid. 1H NMR (300 MHz, DMSO-d6) δ 6.73 (dd, J=3.4, 1.8 Hz, 1H), 7.3 (dd, J=3.1 Hz, 1H), 7.98 (s, 1H), 8.49(s, 1H), 8.69 (br. s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07674791B2 |
| 出典データセット | uspto-grants-2010_03 |
| ORD ID | ord-e652283c74b74d7c9aa07581e79364ed |
| 出典メモ | uspto-grants-2010_03 |