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N-bromobutanimide → Methyl alpha-bromo-2-chlorophenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | Methyl (2-chlorophenyl)acetate | HCID 93683 | — |
| 触媒 | Hydrogen Bromide | HCID 260 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Methyl alpha-bromo-2-chlorophenylacetate | HCID 10730282 | — |
反応手順
A stirred mixture of 36.9 g of methyl o-chlorophenylacetate, 36.0 g of N-bromosuccinimide, and 2 drops of 48% hydrobromic acid in 500 ml of carbon tetrachloride is refluxed for 20 hours and then filtered through magnesium silicate. Evaporation under reduced pressure gives methyl α-bromo-o-chlorophenylacetate as a straw-colored liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04231935 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-0727808507f14d0a92aabc1d744f2376 |
| 出典メモ | uspto-grants-1980_11 |