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4-(2,5,6-Trichloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester → Piperidin-4-yl-(2,5,6-trichloro-pyrimidin-4-yl)-amine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(2,5,6-Trichloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester | HCID 86618554 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Piperidin-4-yl-(2,5,6-trichloro-pyrimidin-4-yl)-amine dihydrochloride | HCID 86618555 | — |
反応手順
A solution of 4-(2,5,6-trichloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.85 g, 2.23 mmol) in 4 M HCl in dioxane (100 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 283.4 [M+H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07674804B2 |
| 出典データセット | uspto-grants-2010_03 |
| ORD ID | ord-3a38878e1ca24ef59931f4ef2f5e73f9 |
| 出典メモ | uspto-grants-2010_03 |