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Triethylamine → 2-(6-{[(Ethylamino)carbonyl]amino}pyridin-3-yl)-N-(1-methyl-1-phenylethyl)-1,3-thiazole-5-carboxamide

HRID 2243050
ノート
印刷プレビュー

反応式

HRID 2243050 の反応式
CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH2:25]([NH:27][C:28]([NH:30][C:31]1[N:36]=[CH:35][C:34]([C:37]2[S:38][C:39]([C:42]([OH:44])=O)=[CH:40][N:41]=2)=[CH:33][CH:32]=1)=[O:29])[CH3:26].CCN(CC)CC.[C:52]([NH2:61])([C:55]1[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=1)([CH3:54])[CH3:53]>CN(C=O)C.O>[CH2:25]([NH:27][C:28]([NH:30][C:31]1[N:36]=[CH:35][C:34]([C:37]2[S:38][C:39]([C:42]([NH:61][C:52]([CH3:54])([C:55]3[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=3)[CH3:53])=[O:44])=[CH:40][N:41]=2)=[CH:33][CH:32]=1)=[O:29])[CH3:26]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 8471TriethylamineHCID 68509CumylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 251261342-(6-{[(Ethylamino)carbonyl]amino}pyridin-3-yl)-1,3-thiazole-5-carboxylic acid

生成物 1

HCID 592084552-(6-{[(Ethylamino)carbonyl]amino}pyridin-3-yl)-N-(1-methyl-1-phenylethyl)-1,3-thiazole-5-carboxamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

HATU (0.078 mg, 0.225 mmol) was added to a solution of 2-(6-{[(ethylamino)carbonyl]amino}pyridin-3-yl)-1,3-thiazole-5-carboxylic acid (Example 17, 60 mg, 0.205 mmol), Et3N (84 μL, 0.41 mmol) and cumylamine (28 mg, 0.205 mmol) in 3 mL DMF. After stirring at room temperature for two hours, the mixture was diluted with water and extracted with EtOAc. The product precipitated during the workup and it was collected by filtration, washed with water and EtOAc and dried (20 mg). MS (ESP): 410 (M+H+) for C21H23N5O2S.

後処理

  1. extractionextracted with EtOAc
  2. customThe product precipitated during the workup and it
  3. filtrationwas collected by filtration
  4. washwashed with water and EtOAc
  5. customdried (20 mg)

出典と根拠

ORDレコード
ord-409de890c2584456b9e4a1b949e4c50c
出典データセット
uspto-grants-2010_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07674801B2

反応ノート

読み込み中…

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