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Carbon Tetrachloride → 1-methyl-3-fluoro-5-phenyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazapin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon Tetrachloride | HCID 5943 | — |
| 反応物 | Acetyl nitrate | HCID 11557 | — |
| 反応物 | 3-Fluoro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one | HCID 13126001 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-methyl-3-fluoro-5-phenyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazapin-2-one | HCID 12811013 | — |
反応手順
1.2 g. of acetyl nitrate are added dropwise, at 10° to a stirred solution of 2.67 g. of 1-methyl-3-fluoro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one in 70 ml. of CCl4 and 20 ml. of acetonitrile. The mixture is stirred for 1 hour more at 10° and for 3 hours at 20° and is poured into ice cold sodium carbonate solution and worked up in the customary manner to give 1-methyl-3-fluoro-5-phenyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazapin-2-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04232016 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-bce5adeb8d2842048ace99c84534f42d |
| 出典メモ | uspto-grants-1980_11 |