Cyanuric chloride → tert-butyl (2R)-2-cyanopyrrolidine-1-carboxylate
反応式
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13](=O)[NH2:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].N1C(Cl)=NC(Cl)=NC=1Cl>CN(C=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13]#[N:14])=[O:7])([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
The title product of Example 10 (10.81 g, 50.45 mmol) and cyanuric chloride (5.58 g, 30.3 mmol) was stirred in DMF (30 mL) for 1 h. The reaction mixture was partitioned between ethyl acetate and water. The organic extracts were washed with aq. sodium carbonate, water, brine dried over sodium sulphate, filtered and concentrated to afford the title product (8.34 g, 84%) as a colourless oil.
後処理
- customThe reaction mixture was partitioned between ethyl acetate and water
- washThe organic extracts were washed with aq. sodium carbonate, water, brine
- dry with materialdried over sodium sulphate
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-bc86d84ef4504911a8a7d9963b65b34e
- 出典データセット
- uspto-grants-2010_03
- 特許番号
- US07678796B2
反応ノート
読み込み中…