Ethanol → Ethyl Pyridazine-4-carboxylate

HRID 2243886

反応式

HRID 2243886 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=[O:8])=[CH:3][N:2]=1.OS(O)(=O)=O.[CH2:15](O)[CH3:16]>>[CH2:15]([O:8][C:7]([C:4]1[CH:5]=[CH:6][N:1]=[N:2][CH:3]=1)=[O:9])[CH3:16]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 2761046Pyridazine-4-carboxylic Acid

生成物 1

HCID 10855652Ethyl Pyridazine-4-carboxylate収率 79%

実験手順

To pyridazine-4-carboxylic acid (1.0 g, 8.1 mmol) in ethanol (10 mL) was added concentrated H2SO4 (4.2 mL) and then heated at reflux for 5 hours. The reaction mixture was cooled, concentrated in vacuo and basified with saturated Na2CO3. After filtration, the aqueous was extracted with ethyl acetate, dried over anhydrous Na2SO4, filtered and concentrated to give the title product as a dark yellow oil (970 mg, 79%).

後処理

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. temperatureThe reaction mixture was cooled
  4. concentrationconcentrated in vacuo
  5. filtrationAfter filtration
  6. extractionthe aqueous was extracted with ethyl acetate
  7. dry with materialdried over anhydrous Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated

出典と根拠

ORDレコード
ord-b84e4f7eedb348819d43d40a83292036
出典データセット
uspto-grants-2010_03
特許番号
US07678796B2

関連ノート

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