Water → Ethyl N-(2,2,2-trifluoroethyl)formimidate

HRID 224414

反応式

HRID 224414 の反応式
Cl.[CH:2](=[NH:6])[O:3][CH2:4][CH3:5].Cl.[F:8][C:9]([F:13])([F:12])[CH2:10]N.C(=O)([O-])[O-].[K+].[K+].O>C(Cl)Cl>[F:8][C:9]([F:13])([F:12])[CH2:10][N:6]=[CH:2][O:3][CH2:4][CH3:5]

参加物

6

反応物 4

HCID 962WaterHCID 97722,2,2-Trifluoroethylamine hydrochlorideHCID 11430Potassium CarbonateHCID 12578842Ethyl formimidate hydrochloride

生成物 1

HCID 20535620Ethyl N-(2,2,2-trifluoroethyl)formimidate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Ethyl formimidate hydrochloride (0.555 g, 5 mmole), 2,2,2-trifluoroethylamine hydrochloride (0.677 g, 5 mmole) and potassium carbonate (0.345 g, 2.5 mmole) are suspended in 20 ml CH2Cl2 and treated with 1 ml H2O. The mixture is shaken vigorously for 3 minutes. The organic phase is separated and the aqueous extracted twice with 10 ml portions of CH2Cl2. The combined organic phase is dried and the CH2Cl2 distilled through a Vigreauxe column to give the Ethyl N-(2,2,2-trifluoroethyl)formimidate. n.m.r. δ1.333 t (CH3CH2); 3.8 q (j=10 c.p.s., CF3CH2) 4.23 q (j=7.5, CH3CH2O); 7.6 S (H--C=N).

後処理

  1. customThe organic phase is separated
  2. extractionthe aqueous extracted twice with 10 ml portions of CH2Cl2
  3. customThe combined organic phase is dried
  4. distillationthe CH2Cl2 distilled through a Vigreauxe column

出典と根拠

ORDレコード
ord-10ed42efae734893945049ee38c86671
出典データセット
uspto-grants-1980_11
特許番号
US04232030

関連ノート

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