Water → HCID 15951607、化合物

HRID 2244217ノート

反応式

HRID 2244217 の反応式
[NH2:1][CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1.[C:9]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:14]=[CH:13][C:12]([C:15]([N:17]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH2:21][N:20]3[C:28]([C:31](=[O:36])C(Cl)(Cl)Cl)=[CH:29][CH:30]=[C:19]3[CH2:18]2)=[O:16])=[CH:11][CH:10]=1.O>O1CCOCC1>[C:9]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:10]=[CH:11][C:12]([C:15]([N:17]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH2:21][N:20]3[C:28]([C:31]([NH:1][CH2:2][C:3]4[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=4)=[O:36])=[CH:29][CH:30]=[C:19]3[CH2:18]2)=[O:16])=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 962WaterHCID 310183-PyridinemethanamineHCID 68687571HCID 68687571、化合物

生成物 1

HCID 15951607HCID 15951607、化合物収率 10.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of 0.216 g (0.002 mol) of 3-aminomethylpyridine and 0.508 g (0.001 mol) of 1-[10-(1,1′-biphenyl-4-ylcarbonyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl]-2,2,2-trichloroethanone of Step B in 25 mL of 1,4-dioxane was heated overnight under reflux with stirring. The cooled reaction mixture was poured into 200 mL of water. The solid was collected and dried to provide the title compound (0.053 g).

後処理

  1. temperatureunder reflux
  2. customThe cooled reaction mixture
  3. customThe solid was collected
  4. customdried

出典と根拠

ORDレコード
ord-683060a84f2f43ee9fd61a4a543bcdbe
出典データセット
uspto-grants-2010_03
特許番号
US07678787B2

反応ノート

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