Acetone → 2'-Methanesulfonyl-biphenyl-4-carboxylic acid

HRID 2244220ノート

反応式

HRID 2244220 の反応式
CS[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([OH:17])=[O:16])=[CH:11][CH:10]=1.[CH3:18]C(C)=O.O[O:23][S:24]([O-:26])=O.[K+]>O>[CH3:18][S:24]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[CH:11][C:12]([C:15]([OH:17])=[O:16])=[CH:13][CH:14]=1)(=[O:26])=[O:23]

参加物

5

反応物 3

HCID 180AcetoneHCID 225963254-(2-Methylthiophenyl)benzoic acidHCID 23707502Potassium hydroxy sulfite

生成物 1

HCID 225963472'-Methanesulfonyl-biphenyl-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 0.977 g (0.004 mole) of 2′-(methylthio)-1,1′-biphenyl-4-carboxylic acid of Example 14, Step A, in 25 mL of water and 75 mL of acetone was added 10 g. (0.163 mole) of oxone. The mixture was stirred overnight at room temperature. The acetone was removed in vacuo, and the residue was collected (0.80 g) and washed with water to provide a solid, m.p. 273-275° C.

後処理

  1. customThe acetone was removed in vacuo
  2. customthe residue was collected (0.80 g)
  3. washwashed with water
  4. customto provide a solid, m.p. 273-275° C.

出典と根拠

ORDレコード
ord-25c7964819074c458752cce0579da0af
出典データセット
uspto-grants-2010_03
特許番号
US07678787B2

反応ノート

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