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2-Aminomethyl-1-ethylpyrrolidine → 2-((3,5-Dibromo-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| 反応物 | N-Ethyl-2-(3-chloro-2,6-dimethoxybenzamidomethyl)pyrrolidine hydrochloride | HCID 15565714 | — |
| 反応物 | 3,5-Dibromo-2,6-dimethoxybenzoic acid | HCID 15565734 | — |
| 溶媒 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | 2-((3,5-Dibromo-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidine hydrochloride | HCID 15565712 | — |
反応手順
Using the same method as for compound of Example 8 this compound is prepared from 20.4 g (0.06 mol) of 3,5-dibromo-2,6-dimethoxybenzoic acid, 50 ml of thionyl chloride and 7.7 g (0.06 mol) of 2-(aminomethyl)-1-ethylpyrrolidine. The obtained product is recrystallized from ethanol-ethyl ether. Yield: 20.2 g, m.p. 164°-65° C. The free base is precipitated from the water solution of the hydrochloric salt by the addition of sodium hydroxide, m.p. 133°-134° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04232037 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-78d54878815845c2814a9c35537df05d |
| 出典メモ | uspto-grants-1980_11 |