p-Chlorophenoxyacetyl chloride → 10-[(4-Chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine

HRID 2244289ノート

反応式

HRID 2244289 の反応式
C1C=CN2CC3C=CC=CC=3NCC=12.ClC1C=CC(OCC(Cl)=O)=CC=1.[Cl:27][C:28]1[CH:51]=[CH:50][C:31]([O:32][CH2:33][C:34]([N:36]2[C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][C:41]=3[CH2:40][N:39]3[CH:47]=[CH:48][CH:49]=[C:38]3[CH2:37]2)=[O:35])=[C:30](C)[CH:29]=1>>[Cl:27][C:28]1[CH:29]=[CH:30][C:31]([O:32][CH2:33][C:34]([N:36]2[C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][C:41]=3[CH2:40][N:39]3[CH:47]=[CH:48][CH:49]=[C:38]3[CH2:37]2)=[O:35])=[CH:50][CH:51]=1

参加物

4

反応物 3

HCID 77771p-Chlorophenoxyacetyl chlorideHCID 1554704810,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepineHCID 6868101910-[(4-Chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine

生成物 1

HCID 6868042910-[(4-Chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine

実験手順

This compound was prepared from 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine and 4-chlorophenoxyacetyl chloride in the same manner as the preparation of 10-[(4-chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine of Example 139, Step B, m.p. 120-122° C.

出典と根拠

ORDレコード
ord-e409af0b14b64b59a6187a3c016ba381
出典データセット
uspto-grants-2010_03
特許番号
US07678787B2

反応ノート

読み込み中…