Hydrochloric Acid → 5-(difluoromethyl)pyridin-3-amine

HRID 2244461ノート

反応式

HRID 2244461 の反応式
C(OC(=O)[NH:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([CH:14]([F:16])[F:15])[CH:13]=1)(C)(C)C.Cl.CCO>C(OCC)(=O)C>[F:15][CH:14]([F:16])[C:12]1[CH:13]=[C:8]([NH2:7])[CH:9]=[N:10][CH:11]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 684058001,1-Dimethylethyl N-[5-(difluoromethyl)-3-pyridinyl]carbamate

生成物 1

HCID 552855075-(difluoromethyl)pyridin-3-amine

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

(5-Difluoromethyl-pyridin-3-yl)-carbamic acid tert-butyl ester (0.30 g, 1.2 mmol) was dissolved in 10 ml ethyl acetate and 8M HCl in EtOH (3 ml, 25 mmol) were added. The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was quenched by addition of 20 ml sat. NaHCO3 solution and extracted three time with 50 ml ethyl acetate. The organic phases were pooled, dried with sodium sulfate and evaporated. The title compound was obtained as a brown oil (0.158 g, 89%).

後処理

  1. customThe reaction mixture was quenched by addition of 20 ml sat. NaHCO3 solution
  2. extractionextracted three time with 50 ml ethyl acetate
  3. dry with materialdried with sodium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-50acdfd076024512a0153b6513d41238
出典データセット
uspto-grants-2010_03
特許番号
US07678815B2

反応ノート

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