化工社化工社 化学情報印刷レポート · 研究参考用
Piperazine → Norquetiapine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | 2-((2-Aminophenyl)thio)benzoic acid | HCID 10955828 | — |
| 生成物 | Norquetiapine | HCID 11369918 | — |
反応手順
Next, 2-(2-aminophenylthio)benzoic acid which is expressed by the above Formula 7 is simultaneously subjected to cyclization and chlorination reactions in the presence of a equivalent amount of halogenating agent and base in an organic solvent, and then reacted with piperazine without separation, to produce 11-piperazinyl-dibenzo[b,f][1,4]thiazepine expressed by the above Formula 4.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07678902B2 |
| 出典データセット | uspto-grants-2010_03 |
| ORD ID | ord-530637aa1d654a4abfb42233554eb700 |
| 出典メモ | uspto-grants-2010_03 |