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Piperazine → 6-Piperazin-1-ylbenzo[b][1,4]benzothiazepine;hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | 2-((2-Aminophenyl)thio)benzoic acid | HCID 10955828 | — |
| 反応物 | Ethanol hydrochloride | HCID 21887872 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-Piperazin-1-ylbenzo[b][1,4]benzothiazepine;hydrochloride | HCID 16202391 | — |
反応手順
Piperazine (53.6 g) was added to the resulting toluene solution, reflux was conducted for 1 hour, and the resulting solution was cooled to room temperature. Washing was carried out with water (125 ml×3) to remove remaining piperazine, and an organic layer was vacuum distilled to produce oil. The oil was dissolved in ethanol, and a hydrochloric acid-ethanol solution was added thereto, to produce 11-piperazinyl-dibenzo[b,f][1,4]thiazepine hydrochloride (46.4 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07678902B2 |
| 出典データセット | uspto-grants-2010_03 |
| ORD ID | ord-2d64ab1928814662957eceaed8ad3f9d |
| 出典メモ | uspto-grants-2010_03 |