Triethylamine → (S)-N-methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide

HRID 22449

反応式

HRID 22449 の反応式
C([N:3]([CH2:6]C)CC)C.[C:8]([NH:15][C@H:16]([C:21]([OH:23])=O)[CH2:17][CH:18]([CH3:20])[CH3:19])([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].[C:24](C1NC=CN=1)(C1NC=CN=1)=[O:25]>ClCCl>[CH3:24][O:25][N:3]([CH3:6])[C:21](=[O:23])[C@H:16]([CH2:17][CH:18]([CH3:19])[CH3:20])[NH:15][C:8]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:9]

参加物

5

反応物 3

HCID 8471Triethylamine2 回HCID 83170L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-HCID 5250894Bis-(1H-imidazol-2-YL)-methanone

生成物 1

HCID 11119284(S)-N-methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Triethylamine (10 ml) is added to a stirred solution of Boc-Leucine in dichloromethane. Then sequentially, carbonyl-diimidazole (10 mmol) are added followed by, N-dimethylhydroxyamine hydrochloride (11 mmol), and triethylamine (11 mmol). The reaction is monitored by TLC, was found to be completely within an hour. The mixture is diluted with dicloromethane (250 ml) and washed successively with 1N HCl, and a saturated sodium chloride solution. The organic solution was dried with magnesium sulfate, and the solvent evaporated to give the desired product (9.0 mmol yield).

後処理

  1. waitto be completely within an hour
  2. washwashed successively with 1N HCl
  3. dry with materialThe organic solution was dried with magnesium sulfate
  4. customthe solvent evaporated

出典と根拠

ORDレコード
ord-56486a97160b42fb8d452a058dc72998
出典データセット
uspto-grants-1995_06
特許番号
US05428019

関連ノート

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