Hydrochloric Acid → HCID 68549802、化合物
反応式
C[O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[CH:10][CH:9]=2)=[O:4].O[Li].O.COC(C)(C)C.[ClH:25]>CO.C1COCC1.O>[ClH:25].[F:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[CH:7]=[N:6][C:5]([C:3]([OH:4])=[O:2])=[CH:14]2参加物
7
実験手順
1 g of the resulting crude 6-fluoro-isoquinoline-3-carboxylic acid methyl ester is dissolved in 20 ml of MeOH/THF (1:1) and slowly mixed at 5° with a solution of 510 mg of LiOH hydrate in 10 ml of water. The resulting solution is stirred at room temperature overnight and poured into a solution consisting of 50 ml of MeOtBu, 10 ml of water and 7 ml of 2N aqu. HCl. The precipitate is filtered off and washed with MeOtBu.
後処理
- additionpoured into a solution
- filtrationThe precipitate is filtered off
- washwashed with MeOtBu
出典と根拠
- ORDレコード
- ord-1b988d3aa9264f63bcab1ae672f80981
- 出典データセット
- uspto-grants-2010_03
- 特許番号
- US07683075B2
反応ノート
読み込み中…