4-Toluenesulfonyl chloride → HCID 23331319、化合物

HRID 224564ノート

反応式

HRID 224564 の反応式
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH2:20][CH:21]([NH2:23])[CH3:22])[CH:17]=[CH:18][CH:19]=1.C(N(CC)CC)C>C1C=CC=CC=1>[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([NH:23][CH:21]([CH3:22])[CH2:20][C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([O:13][CH3:12])[CH:15]=2)(=[O:9])=[O:8])=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 73974-Toluenesulfonyl chlorideHCID 8471TriethylamineHCID 1522341-(3-Methoxyphenyl)propan-2-amine

生成物 1

HCID 23331319HCID 23331319、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

A solution of p-toluenesulfonyl chloride (28.0 gm., 0.15 M) in benzene (100 ml.) was added dropwise to a solution of 2-(3-methoxyphenyl)-1-methylethylamine (23 gm., 0.139 M) and triethylamine (13 gm., 0.15 M) in benzene (200 ml.) during 30 minutes. The reaction was stirred at room temperature for 4 hours. The precipitated triethylamine hydrochloride was filtered off and the benzene solution was washed with hydrochloric acid (3N), water and saturated brine. The benzene solution was dried over magnesium sulfate. Evaporation of the solvent afforded N-toluene-p-sulfonyl-2-(3-methoxyphenyl)-1-methylethylamine as an oil Wt=42 gm.

後処理

  1. filtrationThe precipitated triethylamine hydrochloride was filtered off
  2. washthe benzene solution was washed with hydrochloric acid (3N), water and saturated brine
  3. dry with materialThe benzene solution was dried over magnesium sulfate
  4. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-f146a0ef8d2247ad996adfed0c77dcdb
出典データセット
uspto-grants-1980_11
特許番号
US04233217

反応ノート

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