4-Chloro-8-(trifluoromethyl)quinoline → HCID 23331699、化合物

HRID 224591

反応式

HRID 224591 の反応式
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:18]=1[C:19]([O:21][CH3:22])=[O:20]>Cl>[F:13][C:12]([F:15])([F:14])[C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[CH:4][CH:3]=[C:2]2[NH:16][C:17]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:18]=1[C:19]([O:21][CH3:22])=[O:20]

参加物

4

反応物 2

HCID 902624-Chloro-8-(trifluoromethyl)quinolineHCID 2783401Methyl 2-amino-5-fluorobenzoate

生成物 1

HCID 23331699HCID 23331699、化合物収率 44.8%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 16 g of 4-chloro-8-trifluoromethylquinoline, 11.62 g of methyl 2-amino-5-fluoro-benzoate and 70 ml of 2 N hydrochloric acid solution was heated to reflux and was allowed to stand overnight at room temperature. The mixture was iced and filtered and the product was empasted with a little water and was vacuum filtered. The recovered crystals were dissolved in methanol and triethylamine was added to the resulting solution until the pH was alkaline. The mixture was iced and filtered and the product was dried to obtain 11.2 g of methyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate melting at 166° C.

後処理

  1. temperatureto reflux
  2. filtrationfiltered
  3. filtrationfiltered
  4. dissolutionThe recovered crystals were dissolved in methanol
  5. additiontriethylamine was added to the resulting solution until the pH
  6. filtrationfiltered
  7. customthe product was dried

出典と根拠

ORDレコード
ord-b82c9c6ff6c04d9e9c80a280606d3ff0
出典データセット
uspto-grants-1980_11
特許番号
US04233305

関連ノート

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