Dimethylamino-ethanol → 2-Dimethylaminoethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate
反応式
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[C:8]2[NH:13][C:14]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17].[CH3:27][N:28]([CH:30](O)C)[CH3:29]>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[C:8]2[NH:13][C:14]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:15]=1[C:16]([O:18][CH2:19][CH2:27][N:28]([CH3:30])[CH3:29])=[O:17]参加物
3
実験手順
Using the process of Example 13, methyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate and dimethylamino-ethanol were reacted to form 2-dimethylaminoethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate which was then dissolved in ethanol. Dry hydrogen chloride in ethanol was added to the solution and anhydrous ether was added to effect precipitation. The mixture was vacuum filtered and the crystals were washed and dried to obtain 2-dimethylamino-ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate hydrochloride melting at 220° C.
後処理
- customwere reacted
出典と根拠
- ORDレコード
- ord-0b55c7c854e442c0bb4f3efd526b67b8
- 出典データセット
- uspto-grants-1980_11
- 特許番号
- US04233305
反応ノート
読み込み中…