4-(3-(Trifluoromethyl)phenyl)-1-piperazineethanol → Ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate

HRID 224594ノート

反応式

HRID 224594 の反応式
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[C:8]2[NH:13][C:14]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17].F[C:28](F)(F)C1C=C(N2CCN(CCO)CC2)C=CC=1>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[C:8]2[NH:13][C:14]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:15]=1[C:16]([O:18][CH2:19][CH3:28])=[O:17]

参加物

3

反応物 2

HCID 2179944-(3-(Trifluoromethyl)phenyl)-1-piperazineethanolHCID 23331699Methyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate

生成物 1

HCID 86737324Ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate

実験手順

Using the procedure of Example 13, methyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate and 2-[-4-(3-trifluoromethylphenyl)-piperazin-1-yl]-ethanol were reacted to obtain 2-[4-3-trifluoromethylphenyl)-piperazin-1-yl]-ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate. The said product was dissolved in absolute ethanol and an ethanolic solution of hydrogen chloride was added thereto followed by anhydrous ether. The mixture crystallized was vacuum filtered and the product was washed with anhydrous ether and was dried to form the desired hydrochloride salt melting at 230°-240° C.

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-6cb0733c43ea4c23ba30073be53b3ff7
出典データセット
uspto-grants-1980_11
特許番号
US04233305

反応ノート

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