Potassium Iodide → 1'-(2-Phenoxyethyl)-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine hydrochloride

HRID 224612

反応式

HRID 224612 の反応式
[O:1]([CH2:8][CH2:9][Cl:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][N:12]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:14]2([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[C:13]1=[O:26].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>O.CN(C)C=O>[ClH:10].[O:1]([CH2:8][CH2:9][N:17]1[CH2:18][CH2:19][C:14]2([C:20]3[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:12]([CH3:11])[C:13]2=[O:26])[CH2:15][CH2:16]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 12156Benzene, (2-chloroethoxy)-HCID 215841551-Methylspiro[indoline-3,4'-piperidin]-2-one

生成物 1

HCID 705944601'-(2-Phenoxyethyl)-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine hydrochloride

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 1.63 g of phenoxyethylchloride, 1.5 g of 1-methyl-2-oxo-indoline-3-spiro-4'-piperidine, 1.44 g of anhydrous potassium carbonate, 0.1 g of potassium iodide and 30 ml of dimethylformamide was stirred at 90°-100° C. for 5 hours. The resulting mixture was poured into water and was extracted with diethylether. The extract was washed with water, dried over anhydrous sodium sulfate and concentrated in vacuo. Thus obtained oil was treated with hydrochloric acid to give 1'-(2-phenoxyethyl)-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine hydrochloride

後処理

  1. extractionwas extracted with diethylether
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo
  5. additionThus obtained oil was treated with hydrochloric acid

出典と根拠

ORDレコード
ord-c453dcfec0cf41048b5306cdb9a7f3c2
出典データセット
uspto-grants-1980_11
特許番号
US04233307

関連ノート

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