2-Chloro-3-methoxypyridine → 2,3-Dimethoxypyridine

HRID 2246188

反応式

HRID 2246188 の反応式
Cl[C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:10][O-:11].[Na+]>CN(C)C=O>[CH3:10][O:11][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 1042522-Chloro-3-methoxypyridineHCID 10942334Sodium Methoxide

生成物 1

HCID 46578092,3-Dimethoxypyridine収率 29%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The 2-chloro-3-methoxypyridine (2) (13 g, 90.6 mmol), from Step I, was stirred with 3-equivalents of sodium methoxide (14.7 g, 271.8 mmol) in dimethylformamide (100 mL) at 100° C. until completion of the reaction. The reaction mixture was then quenched with water and extracted with dichloromethane. The combined extracts were washed with water, concentrated and distilled (74° C.; 5 mm Hg) to give the product, 2,3-dimethoxypyridine (3), as a clear oil (7 g; 29% yield for two steps).

後処理

  1. customThe reaction mixture was then quenched with water
  2. extractionextracted with dichloromethane
  3. washThe combined extracts were washed with water
  4. concentrationconcentrated
  5. distillationdistilled (74° C.; 5 mm Hg)

出典と根拠

ORDレコード
ord-7fa384e2807d4d1789c437b8efa79210
出典データセット
uspto-grants-2010_03
特許番号
US07687487B2

関連ノート

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