Benzene → n-Heptyl-diethyl-thiourea

HRID 224630

反応式

HRID 224630 の反応式
[CH2:1]([N:8]=[C:9]=[S:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH2:11]([NH:13]CC)[CH3:12].[CH:16]1C=CC=C[CH:17]=1>>[CH2:1]([N:8]([CH2:16][CH3:17])[C:9]([NH:13][CH2:11][CH3:12])=[S:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

参加物

4

反応物 3

HCID 241BenzeneHCID 8021DiethylamineHCID 78152Heptane, 1-isothiocyanato-

生成物 1

HCID 20555250n-Heptyl-diethyl-thiourea

実験手順

To a solution of 3.14 grams (0.02 mole) of heptyl isothiocyanate dissolved in 15 milliliters of benzene was added 1.46 grams (0.02 mole) of diethylamine. The temperature rose to about 50° C. The mixture was refluxed on a steam bath for 20 minutes until a neutral pH was obtained. The mixture was then evaporated under vacuum to give 4.8 grams of n-heptyl-diethyl-thiourea. To this product, 4.1 grams (0.02 mole) of bromoethylamine hydrobromide and 25 milliliters of ethanol 2B was added. The mixture was refluxed on a steam bath for four hours and then permitted to stand overnight at ambient temperature. The mixture was then refluxed an additional three hours. The mixture was evaporated under vacuum to yield 8.83 grams of a yellow gel-like liquid, ND30 =1.5410. The structure of the product was confirmed by NMR.

後処理

  1. customrose to about 50° C
  2. temperatureThe mixture was refluxed on a steam bath for 20 minutes until a neutral pH
  3. customwas obtained
  4. customThe mixture was then evaporated under vacuum

出典と根拠

ORDレコード
ord-6eeeb19703db41dd8f6ffd9972ba5eb5
出典データセット
uspto-grants-1980_11
特許番号
US04233318

関連ノート

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