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Oxalic acid dihydrate → N,N-dimethyl-3-[3-[(1-methylthio-2-nitroethenyl)amino]propoxy]benzenemethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalic acid dihydrate | HCID 61373 | — |
| 反応物 | 1,1-Bis(methylsulfanyl)-2-nitroethane | HCID 12372264 | — |
| 反応物 | 3-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine | HCID 12913950 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N,N-dimethyl-3-[3-[(1-methylthio-2-nitroethenyl)amino]propoxy]benzenemethanamine | HCID 70538402 | 64% |
反応手順
3-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine (10 g) and 1,1-bis-(methylthio)-2-nitroethane (16 g) were heated under reflux in tetrahydrofuran for 19 hours. Oxalic acid dihydrate (1.3 g) was added and the resulting precipitate was discarded. The solvent was removed to leave the title compound as a crystalline solid (10 g) m.p. 59°-63°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04233302 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-0168655c41f94fc4b8df7f4e22af38e2 |
| 出典メモ | uspto-grants-1980_11 |