1,1-Bis(methylsulfanyl)-2-nitroethane → N,N'-bis-[2-[[5-[[Hydroxy(methyl)amino]methyl]-2-furanylmethyl]thio]ethyl]-2-nitro-1,1-ethenediamine

HRID 224648

反応式

HRID 224648 の反応式
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[O:10][C:9]([CH2:11][N:12]([OH:14])[CH3:13])=[CH:8][CH:7]=1.CS[CH:17](SC)[CH2:18][N+:19]([O-:21])=[O:20]>>[OH:14][N:12]([CH2:11][C:9]1[O:10][C:6]([CH2:5][S:4][CH2:3][CH2:2][NH:1][C:17]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]2[O:10][C:9]([CH2:11][N:12]([OH:14])[CH3:13])=[CH:8][CH:7]=2)=[CH:18][N+:19]([O-:21])=[O:20])=[CH:7][CH:8]=1)[CH3:13]

参加物

3

反応物 2

HCID 123722641,1-Bis(methylsulfanyl)-2-nitroethaneHCID 205594295-[[(2-aminoethyl)thio]methyl]-N-hydroxy-N-methyl-2-furanmethanamine

生成物 1

HCID 20559448N,N'-bis-[2-[[5-[[Hydroxy(methyl)amino]methyl]-2-furanylmethyl]thio]ethyl]-2-nitro-1,1-ethenediamine収率 45.6%

実験手順

A mixture of 5-[[(2-aminoethyl)thio]methyl]-N-hydroxy-N-methyl-2-furanmethanamine base (1.48 g) and 1,1-bis-(methylthio)-2-nitroethane (0.57 g) was heated at 98°-100° for 3 hr. The oily residue was chromatographed (silica/acetone) and the appropriate eluate evaporated to give the title compound (0.78 g) as an amber oil.

後処理

  1. temperaturewas heated at 98°-100° for 3 hr
  2. customThe oily residue was chromatographed (silica/acetone)
  3. customthe appropriate eluate evaporated

出典と根拠

ORDレコード
ord-28283947f76943ffb984dca104ab2436
出典データセット
uspto-grants-1980_11
特許番号
US04233302

関連ノート

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