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Tert-Butylamine → N-tert. butyl-4-,5-dimethylfuran-3-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tert-Butylamine | HCID 6385 | — |
| 反応物 | Phosphorus pentachloride | HCID 24819 | — |
| 反応物 | 2,3-Dimethylfuran | HCID 34337 | — |
| 反応物 | 5-Methyl-2-sulfamoyl-furan-3-carboxylic acid | HCID 20471898 | — |
| 反応物 | 4,5-Dimethyl-furan-2-sulfonic acid sodium salt | HCID 88714704 | — |
| 生成物 | N-tert. butyl-4-,5-dimethylfuran-3-sulfonamide | HCID 86737331 | 34% |
反応手順
Analogous to the preparation of the 5-methyl-2-sulfamoyl-furan-3-carboxylic acid (see starting compound of Example 1), 2,3-dimethyl-furan [K. C. Rice and J. R. Dyer, J. Heterocycl. Chem. 12, 1325 (1975)] was converted with sulfur trioxide-pyridine complex into the 4,5-dimethyl-furan-2-sulfonic acid sodium salt and treated with phosphorus pentachloride and tert. butylamine. N-tert. butyl-4-,5-dimethyl-furan-3-sulfonamide was obtained with a yield of 34% of theory. M.p. 95°-96° C. (from petroleum ether).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04233333 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-8b93a81753ca48d6b28337f1b76e719a |
| 出典メモ | uspto-grants-1980_11 |