Boron tribromide → 5-Hexyl-2-phenoxyphenol

HRID 2246761ノート

反応式

HRID 2246761 の反応式
[CH2:1]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:9]([O:20]C)[CH:8]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].ClC1C=CC(OC2C=CC=CC=2)=C(OC)C=1.B(Br)(Br)Br>ClCCl>[CH2:1]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:9]([OH:20])[CH:8]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

5

反応物 3

HCID 25134Boron tribromide2 回HCID 586041314-Chloro-2-methoxy-1-phenoxybenzeneHCID 684255854-Hexyl-2-methoxy-1-phenoxybenzene

生成物 1

HCID 52749775-Hexyl-2-phenoxyphenol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
-70 °C

実験手順

Compound (4a), 1.4 mmol, was dissolved in 3 mL of anhydrous dichloromethane under nitrogen. The temperature of the solution was lowered to −70° C. To the solution of (3) was added 455 mg (1.8 mmol) of boron tribromide (1.8 mL of a 1.0M boron tribromide in dichloromethane solution). The reaction mixture was stirred at −70° C. for one hour, followed by stirring at room temperature for three hours. The reaction progress was monitored by thin layer chromatography. The solution was then quenched with methanol at −70° C. and concentrated. A suspension of the concentrate was washed with 10% aqueous sodium bicarbonate solution. The organic phase was removed, washed with water and then brine (NaCl), dried over anhydrous magnesium sulfate, filtered, and concentrated under vacuum to give the crude product. Purification by flash chromatography on silica gel afforded the analytically pure product (5a): 1H NMR (300 MHz) (CDCl3): δ 7.44-6.76 (m, 8H), 5.58 (s, 1H), 2.66-2.61 (t, 2H), 1.71-1.66 (m, 2H), 1.40-1.34 (m, 6H), 1.00-0.95 (t, 3H).

後処理

  1. customwas lowered to −70° C
  2. stirringby stirring at room temperature for three hours
  3. customThe solution was then quenched with methanol at −70° C.
  4. concentrationconcentrated
  5. additionA suspension of the concentrate
  6. washwas washed with 10% aqueous sodium bicarbonate solution
  7. customThe organic phase was removed
  8. washwashed with water
  9. dry with materialbrine (NaCl), dried over anhydrous magnesium sulfate
  10. filtrationfiltered
  11. concentrationconcentrated under vacuum
  12. customto give the crude product
  13. customPurification by flash chromatography on silica gel

出典と根拠

ORDレコード
ord-356d5982c9c74312ae73529e81802e32
出典データセット
uspto-grants-2010_03
特許番号
US07687547B2

反応ノート

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