HCID 21959544、化合物 → HCID 21049551、化合物
反応式
[CH3:1][C:2]1([CH3:21])[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-])=O)=[CH:8][CH:9]=2)[N:4]([CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[CH2:3]1>CO>[CH3:1][C:2]1([CH3:21])[C:10]2[C:5](=[CH:6][C:7]([NH2:11])=[CH:8][CH:9]=2)[N:4]([CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[CH2:3]1参加物
3
試薬・触媒・溶媒 1
実験手順
3,3-Dimethyl-1-(1-methyl-piperidin-4-yl)-6-nitro-2,3-dihydro-1H-indole (600 mg, Step E) was dissolved in MeOH (20 mL), the mixture was bubbled with H2 for 10 min. 10% Pd/C (100 mg) was added and the mixture was stirred under H2 overnight. The mixture was filtered through Celite® and concentrated in vacuo to afford the title compound as an oil. MS:260 (M+1). Calc'd. for C16H25N3—259.39.
後処理
- customthe mixture was bubbled with H2 for 10 min
- addition10% Pd/C (100 mg) was added
- filtrationThe mixture was filtered through Celite®
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-0eb1f67732844905a09ddecad6294a3f
- 出典データセット
- uspto-grants-2010_03
- 特許番号
- US07687643B2
反応ノート
読み込み中…