Thiourea → 5-(3-Methanesulphonyl-phenyl)-4-methyl-thiazol-2-ylamine hydrobromide

HRID 2247399ノート

反応式

HRID 2247399 の反応式
[Br:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[NH2:16][C:17]([NH2:19])=[S:18]>>[BrH:1].[CH3:15][S:12]([C:8]1[CH:7]=[C:6]([C:2]2[S:18][C:17]([NH2:19])=[N:16][C:3]=2[CH3:4])[CH:11]=[CH:10][CH:9]=1)(=[O:14])=[O:13]

参加物

3

反応物 2

HCID 2723790ThioureaHCID 858616531-Bromo-1-(3-methanesulphonyl-phenyl)-propanone

生成物 1

HCID 865984455-(3-Methanesulphonyl-phenyl)-4-methyl-thiazol-2-ylamine hydrobromide

実験手順

A stirred solution of 1-bromo-1-(3-methanesulphonyl-phenyl)-propanone (176c) (0.32 g, 1.01 mmol) is treated with thiourea (0.067 g, 0.88 mmol) added in one portion. The reaction mixture is allowed to stir at room temperature over two days. The product precipitates out and is filtered to yield the title compound as while solid.

後処理

  1. additionadded in one portion
  2. customThe product precipitates out
  3. filtrationis filtered

出典と根拠

ORDレコード
ord-59f736901d8149fba120e1317130c35c
出典データセット
uspto-grants-2010_03
特許番号
US07687637B2

反応ノート

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