関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 反応物 | 4-Hydroxycoumarin | HCID 54682930 | — |
| 溶媒 | Ethylene Glycol | HCID 174 | — |
| 生成物 | 4-Aminocoumarin | HCID 820807 | 99.4% |
反応手順
97.2 g of 4-hydroxycoumarin and 69.3 g of ammonium acetate in 300 ml of ethylene glycol are heated to 70° C. for 3 hours, whilst stirring, and to 160° C. for 6 hours, the mixture is cooled to 60° C., 1 liter of water is added, whilst stirring, and the mixture is cooled to room temperature. The colourless crystalline precipitate is filtered off, washed with water and dried in vacuo at 60° C. 96 g of 4-aminocoumarin in an almost pure form are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04234488 |
|---|
| 出典データセット | uspto-grants-1980_11 |
|---|
| ORD ID | ord-a991ef93bd7c452db36474033f77f721 |
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| 出典メモ | uspto-grants-1980_11 |
|---|
